Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal Microdevice
نویسندگان
چکیده
منابع مشابه
Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal Microdevice.
Ovarian cancer is characterized by extensive peritoneal metastasis, with tumor spheres commonly found in the malignant ascites. This is associated with poor clinical outcomes and currently lacks effective treatment. Both the three-dimensional (3D) environment and the dynamic mechanical forces are very important factors in this metastatic cascade. However, traditional cell cultures fail to recap...
متن کاملA novel p70 S6 kinase-microRNA biogenesis axis mediates multicellular spheroid formation in ovarian cancer progression
Ovarian cancer is the leading cause of death of all gynecologic tumors, associated with widespread peritoneal dissemination and malignant ascites. Key to this is the ability to form multicellular spheroids (MCS); however, the tumor-specific factors that regulate MCS formation are unclear. p70 S6 kinase (p70S6K), which is a downstream effector of phosphatidylinositol 3-kinase/Akt, is frequently ...
متن کاملp70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/β1 integrin signaling activation
Peritoneal dissemination as a manifestation of ovarian cancer is an adverse prognostic factor associated with poor clinical outcome, and is thus a potentially promising target for improved treatment. Sphere forming cells (multicellular spheroids) present in malignant ascites of patients with ovarian cancer represent a major impediment to effective treatment. p70 S6 kinase (p70S6K), which is a d...
متن کامل3D and 4D Seismic Data Integration in Static and Dynamic Reservoir Modeling: A Review
Reservoir modeling is the process of generating numerical representations of reservoir conditions and properties on the basis of geological, geophysical, and engineering data measured on the Earth’s surface or in depth at a limited number of borehole locations. Therefore, reservoir modeling requires an incorporation of the data from a variety of sources, along with an integration of knowledge a...
متن کاملAgent-Based Simulations of In Vitro Multicellular Tumor Spheroid Growth
Multicellular tumor spheroids (MTS) are an in vitro model system of avascular tumors. They are used to study how local microenvironments affect cellular growth, viability, and therapeutic response. We are developing in silico, agent-based analogues to provide new options for gaining exploitable insight into both the in vitro and in vivo systems. MTS exhibit characteristic phenotypic attributes:...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2017
ISSN: 1940-087X
DOI: 10.3791/55337